Decoding and Encoding Immunity with AI

BayVax Biotech leverages cutting-edge AI models to predict immune responses, design novel antigens, and accelerate the development of personalized and broad-spectrum vaccines.

AI-Powered Immune Programming

Our proprietary models surpass traditional methods by simulating biological systems with up-to-date AI architecture

Immune Discriminator

Cross-attention mechanisms simulate peptide-MHC-TCR binding to predict immunogenicity beyond traditional algorithms.

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Immune Generator

TCR generator can create TCR sequences targeting hotspot mutations with high positive rate.

Immune Toolbox

End-to-end solutions from HLA typing to epitope prediction and generative design.

Clinical Validation

Proven efficacy in investigator-initiated trial with promising progression-free survival extension.

Precision Immunotherapy Applications

From research to clinical implementation

Digital Pipelines

Commercialize digital pipelines through licensing and partnerships.

Personalized Cancer Vaccines

Patient-specific neoantigen sequences for solid tumors with significantly extended PFS.

Broad-Spectrum Vaccines

AI-designed antigens for infectious diseases with enhanced cross-reactivity.

Clinical Milestones

Validating our AI models through rigorous research

Pipelines

Vaccine Type Prototype In-silico Study Animal Study IND-enabling
Neoantigen Cancer Vaccine Peptide IIT
Pan-coronavirus Vaccine Viral Vector
Senolytic(Anti-aging) Vaccine Protein
Autoimmune Disease Vaccine Peptide
2025

IND Application

Regulatory pathway opened for neoantigen vaccines following first FDA approval.

2023

Controlled IIT Launched

Investigator-initiated trials at HKU-Shenzhen Hospital show promising PFS extension.

Before 2022

Single arm IIT

Previous IITs in solid tumours (HCC, MSS-CRC) showed significantly extended PFS.

Research Publications

Our latest scientific contributions to immunology and vaccine development

SPRINT for Benchmarking Sequence-based Immunogenicity PRedIction NeTworks
YIN Yj, LI Hz, MA Jh, CHEN Wj, YU Yy, ZHANG Xy, QU Ty, HUANG J-D*, HU Y-F*, CHEN Yf*
Research Gate
2025-05-30
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Remodeling peptide-MHC-TCR triad binding as sequence fusion for immunogenicity prediction
MA Jh, LI Hz, HUANG J-D*, HU Y-F*, CHEN Yf*
arXiv
2025-01-03
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Distinct evolution patterns of influenza viruses and implications for vaccine development
HU Y-F*, ZHANG B-Z, CHU H*, HUANG J-D*
The Innovation
2025-01-06
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Lineage-specific pathogenicity, immune evasion, and virological features of SARS-CoV-2 BA.2.86/JN.1 and EG.5.1/HK.3
LIU Yc†, ZHAO Xy†, SHI Jl†, WANG Yj†, LIU H†, HU YF†, (…), HUANG J-D, YUEN K-Y, TO KK-W, CHAN JF-W, ZHANG B-Z*, SUN L*, WANG Pf*, CHU H*
Nature Communications
2024-10-09
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Personalized tumor neoantigen peptide vaccine combined with radiotherapy in the treatment of advanced tumors-phase II randomized group study
ZHANG Y*, LI R, HU YF, DAI W, WANG J, XU ZY, SU Xp, HUANG J-D, KONG FM
International Journal of Radiation Oncology, Biology, Physics
2024-10-01
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Family-specific training improves linear B cell epitope prediction for emerging viruses
LIU R, HU Y-F, DU J, ZHANG B-Z, YAU T, FAN X*, HUANG J-D*
IEEE/ACM Transactions on Computational Biology and Bioinformatics
2023-09-04
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Rational design of a booster vaccine against COVID-19 based on antigenic distance
HU Y-F, YUEN T T-T, GONG H-R, HU Bj, HU Jc, (…), ZHANG B-Z*, CHU H*, HUANG J-D*
Cell Host & Microbe
2023-08-09
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A Bayesian approach to estimate MHC-peptide binding threshold
LIU R, HU Y-F, HUANG J-D*, FAN X*
Briefings in Bioinformatics
2023-06-02
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Join the Wave of AI-powered Immune Programming

Collaborate on IND applications, licensing, or co-development

Contact Information

admin@bayvaxbio.com

+852 5615 7942

15221876358

Shenzhen, China

Hong Kong, China

Closed Tender

The Results of Proposal for IND-Enabling Toxicity Study Will be Released on June 13, 2025

Project Title Preclinical Toxicity Study for Peptide-Based Neoantigen Cancer Vaccine
Reference No TOX-2025-001
Budget Not exceeding HKD 1,500,000
Deadline June 6, 2025

1. Background

We seek qualified Contract Research Organizations (CROs) to conduct an IND-enabling toxicity study for a peptide-based neoantigen cancer vaccine. This study is critical to support Investigational New Drug (IND) applications to the Center for Drug Evaluation (CDE) in China and the U.S. Food and Drug Administration (FDA).

2. Scope of Work

The selected CRO must deliver:

  • Toxicology Studies:
    • Repeat-Dose Toxicity
    • Immunogenicity and Immunotoxicity Assessment
  • Regulatory Compliance:
    • Align with FDA eCTD requirements and CDE guidelines.

3. Eligibility Criteria

  • Experience: Proven track record in oncology vaccine preclinical studies
  • Regulatory Expertise: Prior successful IND submissions to FDA and CDE
  • Facilities: AAALAC-accredited laboratories with GLP certification

4. Evaluation Criteria

Criterion Weight
Scientific & Technical Merit 40%
Regulatory Compliance 30%
Cost-Effectiveness 20%
Past Performance 10%

5. Timeline

  • Submission Deadline: June 6, 2025
  • Contract Award: June 13, 2025
  • Study Start: July 1, 2025
  • Final Report Delivery: May 15, 2026

Contact Information

Procurement Manager: Ms May Chen

Email: may.chen@bayvaxbio.com

Note: Proposals exceeding the budget cap will be disqualified. Inquiries must be submitted by June 10, 2025.